Pcyt1a cancer
SpletExpression of PCYT1A in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. SpletPhosphate cytidylyltransferase 1, choline, alpha. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. PCYT1A (CT, CTPCT, …
Pcyt1a cancer
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Splet01. avg. 2024 · Mechanically, PCYT1A served as a novel negative regulator of mTORC1 signaling. PCYT1A knockdown enhanced the malignant proliferation and migration of … Splet07. jul. 2024 · Collectively, PCYT1A was upregulated by MYC, which resulted in the induction of aberrant choline metabolism and the inhibition of B-lymphoma cell …
Splet03. dec. 2015 · As a lipid-modifying enzyme, PCYT1A was controlled by MYC and attributed to dysregulation of choline metabolism. Functioned as a sensitive biomarker of lymphoma progression, PCYT1A could be targeted by lipid-lowering agent Berberine, providing a novel therapeutic strategy in treating MYC-driven lymphoma. Figure 1. View large Download slide Splet02. jan. 2014 · Located at 3q29, PCYT1A ( Figure 3) contains 10 exons, is ubiquitously expressed, and encodes CCTα, an amphitropic enzyme that catalyzes the synthesis of CDP-choline from phosphocholine and CTP.
Splet07. jul. 2015 · 140544 (Pcyt1a) 09106 Metabolism of other amino acids 00440 Phosphonate and phosphinate metabolism 140544 (Pcyt1a) 09160 Human Diseases 09161 Cancer: overview 05231 Choline metabolism in cancer 140544 (Pcyt1a) Enzymes [BR:rno01000] 2. Transferases 2.7 Transferring phosphorus-containing groups 2.7.7 … SpletObjectives: The aim of this study was to test choline-phosphate cytidylyltransferase-α (CCT-α) protein as a biomarker for neoadjuvant cisplatin chemotherapy response in a bladder tumor setting. Materials and methods: A total of 238 patients with T2-T4 bladder cancer enrolled into two prior randomized trials comparing neoadjuvant cisplatin-based …
Splet21. nov. 2012 · Similar to the subcellular localization of ERCC1, IHC tests demonstrated that PCYT1A is localized mainly on nuclear membrane. In this study, we also discovered that the PCYT1A gene expression level is significantly higher than the ERCC1 gene expression level in a certain population of lung cancer patient tissue samples.
SpletWe observed that the loss of PCYT1A activity also caused alterations in mitochondrial morphology, with the shape of mitochondria becoming more rounded, with no apparent deformations of... home necessities cortlandSplet21. mar. 2024 · PCYT1B (Phosphate Cytidylyltransferase 1B, Choline) is a Protein Coding gene. Diseases associated with PCYT1B include Froelich Syndrome and Newborn … hinge 175l660-01.22Splet17. avg. 2010 · Conversion of PCho to CDP-choline is mediated through the alpha and beta isoforms of phosphate cytidylyl transferase 1 (PCYT1A and PCYT1B). The expression of … hinge 2 releaseSplet13. maj 2024 · m 5 C methyltransferases, especially NSUN2, regulates substrate levels by catalyzing m 5 C modification of target RNA to mediate the crosslinking of a series of oncogenic or antitumor factors, thus affecting tumorigenesis and cancer progression. hinge 2060rSplet01. avg. 2024 · Lung cancer is one of most common malignant cancer worldwide. It is emerging that PCYT1A, a rate-limiting enzyme required for the biosynthesis of phosphatidylcholine, is associated with cancer ... hinge 3d cadSpletCancer Conservation Protein Mutation Frequency in Cancer The 'lollipop plot' above illustrates recurrent (observed in 3 or more out of 4440 TCGA tumor samples from 15 … home necessitySplet21. nov. 2012 · To examine the gene expression levels for ERCC1 and PCYT1A in different cancer patient tissue samples, we performed qPCR analysis on OriGene’s lung cancer … hinge 15 inch macbook dock