WebB cells require IRF4 to mediate chronic transplant rejection. IRF4 ablation in B cells abrogates allogeneic B cell responses and may also inhibit the ability of B cells to prime … WebJP7239597B2 JP2024545734A JP2024545734A JP7239597B2 JP 7239597 B2 JP7239597 B2 JP 7239597B2 JP 2024545734 A JP2024545734 A JP 2024545734A JP 2024545734 A JP2024545734 ...
IRF4 - Wikipedia
WebMar 19, 2024 · To determine the transcriptional targets controlled by IRF4, we next performed ChIP-seq analysis in TL-Om1 cells. Given that both IRF4 and NF-κB are aberrantly activated in ATL cells, we hypothesized that IRF4 may cooperate with NF-κB in ATL cells, and hence performed ChIP-seq analysis for p65, one of the major subunits of NF-κB, in the … WebJan 1, 2015 · Anaplastic large cell lymphoma (ALCL) is a distinct entity of T-cell lymphoma that can be divided into 2 subtypes based on the presence of translocations involving the ALK gene (ALK + and ALK − ALCL). The interferon regulatory factor 4 (IRF4) is known to be highly expressed in both ALK + and ALK − ALCLs. However, the role of IRF4 in the … hidden valley low fat ranch dressing
IRF4 overexpression promotes the transdifferentiation of tregs …
WebInterferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene,.IRF4 functions as a key regulatory transcription factor in the development of human immune cells. The expression of IRF4 is essential for the differentiation of T lymphocytes and B lymphocytes as well as certain myeloid cells. … WebOct 6, 2024 · Transient expression of IRF4 in B cells induces the expression of BCL-6 and POU2AF1 and promotes GC development 32. IRF4 expression is rapidly induced by BCR … WebApr 8, 2024 · These cells showed a downregulation of Pax5 compared to other B cells. Within Blimp-1 + IRF4 + B cells, IgM-, IgG-, and IgA-expressing cells were identified and immunoglobulin-class distribution was clearly different between the anatomical locations, with IgA + PCs dominating in lung tissue and IgM + PCs dominating in the spleen. … howell hotels