Fundc1 phosphorylation
WebJan 1, 2024 · Mechanically, silencing of NLRX1 further observably enhanced the relative levels of -phosphorylated FUNDC1/FUNDC1, and NLRP3 inflammasome-related proteins, while overexpression of NLRX1 exhibited inverse results in the H 2 O 2 … WebMar 26, 2014 · Mass spectrometric analysis of cellular phosphoproteome revealed that FUNDC1 has a potential phosphorylation site at Ser-17 …
Fundc1 phosphorylation
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WebIn particular, phosphorylation of ubiquitin by PINK1 is important for triggering this pathway. Likewise, adapter proteins such as p62, optineurin (OPTN) and FUNDC1 have been … WebOn the other hand, in the model of cardiac ischemia/reperfusion injury, receptor-interacting serine/threonine-protein kinase 3 (RIPK3) can inhibit FUNDC1-mediated mitophagy and then promote myocardial cell apoptosis, which proves that phosphorylation is involved in regulating FUNDC1-mediated mitophagy [44].
WebMar 31, 2024 · FUNDC1 is an integral molecule localized to the outer mitochondrial membrane that can interact with the LC3 protein to activate mitophagy, by altering its phosphorylation states (12). WebMar 17, 2024 · During hypoxia, the interaction of FUNDC1 with LC3/GABARAP proteins is determined by the phosphorylation of Ser13, which is regulated by the interplay of a phosphoglycerate mutase (PGAM5) phosphatase and casein kinase 2 [ [ 73] ]. p62 function in autophagy is also regulated by various kinases.
WebDec 17, 2024 · Under normoxic conditions, the activity of FUNDC1 is inhibited due to phosphorylation of FUNDC1 at Ser13 and Tyr18 by CK2 or Src, respectively. The phosphatase PGAM5 dephosphorylates FUNDC1 at Ser13, which is inhibited by Bcl-xL in normal conditions. In response to mitophagy stimuli, Bcl-xL is degraded and PGAM5 is … WebSep 2, 2024 · Emerging evidence has demonstrated that levels and phosphorylation states of FUNDC1 are closely related to occurrence, progression and prognosis of various …
WebNov 15, 2024 · Since the phosphorylation of FUNDC1 at Ser17 by ULK1 can enhance its binding affinity to LC3B and promote mitophagic activity , we measured p (Ser17)-FUNDC1 and ULK1 levels. Our results indicated that p (Ser17) -FUNDC1 and ULK1 protein levels were significantly decreased in HL-1 cardiomyocytes in response to Ang-II stimulation, …
http://www.labbase.net/News/ShowNewsDetails-4-12-E0D551209ED5ABFE.html symposium by xenophonWebInterestingly, FUNDC1 seems to play a less important role in starvation-induced mitophagy or CCCP-induced mitophagy, suggesting different mechanisms may be responsible for mitophagy that occurs in response to different stress conditions. Similar to the case of Atg32 and BNIP3L, FUNDC1-mediated mitophagy is also regulated by its phosphorylation. thaibundeeWebDescription: Homo sapiens FUN14 domain containing 1 (FUNDC1), mRNA. (from RefSeq NM_173794) RefSeq Summary (NM_173794): This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known. [provided by RefSeq, Sep 2011]. Gencode Transcript: ENST00000378045.5 thai bundallWebDec 13, 2024 · Our data suggested that FUNDC1 can be used as a prognostic biomarker in patients with cervical cancer, and may be a new therapeutic target to improve the … symposium cafe markhamWebOct 5, 2024 · Similar to BNIP3 and Nix, FUNDC1 directly binds to LC3 through a conserved LIR motif in its N-terminal region to mediate mitophagy. 59 FUNDC1-mediated mitophagy is mainly regulated by phosphorylation and dephosphorylation at Ser13 and Tyr18 residues located in the LIR motif. In general, Ser13 and Tyr18 residues can be phosphorylated by … thai bulverdeWebJan 22, 2012 · Here we report that FUNDC1, an integral mitochondrial outer-membrane protein, is a receptor for hypoxia-induced mitophagy. FUNDC1 interacted with LC3 through its typical LC3-binding motif Y (18)xxL (21), and mutation of the LC3-interaction region impaired its interaction with LC3 and the subsequent induction of mitophagy. thai bunburyWebMar 26, 2014 · ULK1-induced phosphorylation enhances FUNDC1 interaction with LC3. Hypoxia and mitochondrial uncouplers upregulate ULK1 and induce its translocation to damaged mitochondria; ULK1 recruitment to mitochondria is regulated by its binding to FUNDC1; At mitochondria, ULK1 directly phosphorylates FUNDC1 at serine-17, which is … symposium champlain 2022