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Fls2 pub12 pub13

WebApr 11, 2015 · Arabidopsis FLS2, the receptor for bacterial flagellin, activates immune signalling by association with its partner BAK1. Upon flagellin (flg22) perception, the plant U-box E3 ubiquitin ligases PUB12 and PUB13 complex with FLS2 in a BAK1-dependent manner, and ubiquitinate FLS2 for protein degradation, thereby down-regulating flagellin … WebJul 13, 2024 · The ARM domains of PUB12/13 are essential for interaction with FLS2–BAK1 complex and phosphorylation by BAK1 ( Zhou et al., 2015a ). In vitro ubiquitination assay showed that PUB12 and PUB13 specifically polyubiquitinate FLS2, but not BAK1 and BIK1, which promotes the degradation of FLS2 ( Lu et al., 2011 ).

823804 - Gene ResultPUB13 plant U-box 13 [ (thale cress)]

WebApr 18, 2013 · Author Summary As a Pattern-Recognition Receptor (PRR) that detects conserved microbial molecules, FLS2 mediates the plant innate immunity responses … WebFeb 5, 2024 · PUB12 and PUB13 were initially identified as BAK1-interacting E3 ligases that regulate FLS2 stability in flg22 signaling (14, 15). Recently, PUB12 and PUB13 were … shepherds armstrong https://ferremundopty.com

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WebJun 17, 2011 · BAK1 phosphorylates PUB12 and PUB13 and is required for FLS2-PUB12/13 association. PUB12 and PUB13 polyubiquitinate FLS2 and promote flagellin … WebMar 31, 2024 · showed that PUB12 and PUB13 contribute to the endocytosis of BRI1, and to its degradation, placing E3 function at the PM, and suggesting that the same may hold true for FLS2 (Fig. ... FLS2 is directly SUMOylated by the SUMO E2 SCE1 and mutation of the SUMO modified Lys1120 to Arg impedes BIK1 release and impairs FLS2-mediated … WebBAKI phosphorylates PUB12 and PUB13 and is required for FLS2-PUB12/13 association. PUB12 and PUB13 polyubiquitinate FLS2 and promote flagellin-induced FLS2 degradation, and the publ2 and publ3 mutants displayed elevated immune responses to flagellin treatment. Our study has revealed a unique regulatory circuit of direct ubiquitination shepherds arms horbury

dominant negative ARM domain uncovers multiple functions of …

Category:Arabidopsis ubiquitin ligase PUB12 interacts with and negatively ...

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Fls2 pub12 pub13

Arabidopsis ubiquitin ligase PUB12 interacts with and …

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Fls2 pub12 pub13

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WebFLS2 is ubiquitinated by two closely related plant U-box E3 ubiquitin ligases, PUB12 and PUB13, and subjected to degradation (Lu et al., 2011). PUB12 and PUB13 interact with BAK1, and are recruited to FLS2 on flg22 perception. BAK1 phosphorylates PUB12 and PUB13 directly,and is required for FLS2 and PUB12/13 association. WebPUB12/13 then polyubiquitinate the cytosolic domain of FLS2 and promote 26 S proteasome-dependent FLS2 degradation, thereby down-regulating the immunity …

WebThe #1 social media platform for MCAT advice. The MCAT (Medical College Admission Test) is offered by the AAMC and is a required exam for admission to medical schools in … WebThe data are shown as means T SEs from three replicates. Asterisk indicates a significant difference with P < 0.05 when compared with data from WT plants. (E) PUB12 and PUB13 promote FLS2 degradation.

WebPUB12 and PUB13 carry out the FLS2 ubiquitination after they are phosphorylated by BAK1, suggesting that BAK1 regulates the FLS2 degradation . Activity of the BAK1 and BIK1 kinases is negatively regulated by phosphatases, however this process may be attenuated upon perception of the pathogen-associated ligand. WebPUB12 and PUB13 polyubiquitinate FLS2 and promote flagellin-induced FLS2 degradation, and the pub12 and pub13 mutants displayed elevated immune responses to flagellin treatment. Our study has revealed a unique regulatory circuit of direct ubiquitination and turnover of FLS2 by BAK1-mediated phosphorylation and recruitment of specific E3 …

WebPharmacological inhibition of poly(ADP-ribose) polymerase (PARP) or loss of Arabidopsis thaliana PARG1 (poly(ADP-ribose) glycohydrolase) disrupt a subset of plant defenses. In the present study we examined the impact of altered poly(ADP-ribosyl)ation

WebOct 20, 2015 · PUB12 and PUB13, two highly homologous U-box E3 ligases, are involved in the regulation of FLS2 turnover 29, and PUB13 is also involved in defence response, cell death and flowering 30. springberg mcandrew insuranceWeb植物受体激酶是细胞外刺激的关键传递因子，如有益或致病微生物的存在或分泌的信号分子。. 受体激酶受到许多翻译后修饰的调节。. 在这篇文章中，科研人员利用免疫受体激酶FLS2和EFR，表明在所有植物受体激酶中保守的半胱氨酸的S-酰化对功能至关重要 ... spring benner walker water authorityWebPUB12 and PUB13 are recruited to the FLS2 complex in response to flg22 (Lu et al., 2011). BAK1 phosphorylation of PUB12/PUB13 leads to FLS2 ubiquitination by the E3 ligases for receptor degradation. Consistent with this, FLS2 signaling outputs and bacterial resistance are enhanced in pub12 pub13 plants. Following ligand-induced association spring benner walker joint authorityWebJun 17, 2011 · Flagellin strongly enhanced the interaction of PUB13 and FLS2, providing key evidence that the association had a possible role in signaling. PUB12, a close homolog of PUB13, also associated with … spring bend park st charles moWebBAK1 phosphorylates PUB12 and PUB13 and is required for FLS2-PUB12/13 association. PUB12 and PUB13 polyubiquitinate FLS2 and promote flagellin-induced FLS2 degradation, and the pub12 and pub13 mutants displayed elevated immune responses to … shepherds arms menuWebSep 20, 2016 · Activated FLS2 is endocytosed, but the degree to which other receptor kinases exhibit similar spatiotemporal dynamics remains unclear. We show that internalization into a common endosomal pathway after ligand perception is a general phenomenon of the tested receptor kinases, including the danger peptide receptor PEPR1. springberry phone casesWeb作为这个整体过程的一部分， fls2 的磷酸化、 sumo 化和泛素化状态发生了变化，表明有高度的翻译后调节。 FLS2 的激活还改变了整体复合体的组成和物理特性，然而，这些变化的机制和相关性在很大程度上仍然是未知的。 spring begins in march